e-ISSN: 2617-7668
print ISSN: 2522-9176
Поздно обратившиеся пациенты с коарктацией аорты страдают от хронической гипертонии, резистентной к фармакотерапии
Обзорная статья
Поздно обратившиеся пациенты с коарктацией аорты страдают от хронической гипертонии, резистентной к фармакотерапии
Опубликован: Июнь 6, 2018
Аннотация
Coarctation of the aorta (CoA) is a common Congenital Heart Disease (CHD) presenting with many symptoms and signs, in any age group. From its dramatic appearance as a part of Hypo plastic Left Heart Syndrome (HLHS), to early Congestive Heart Failure(CHF)in neonatal and early infantile age, to undetected Hypertension (HTN) in early or even late adulthood. The aim of this short review is to present this unique CHD, underline the presentation of late detected CoA, presenting with HTN and its impact in treating resistant HTN even after successful surgical treatment. Finally, the late onset HTN, following successful surgical treatment and its medicine management will be addressed. This difficult to control on mono or dual pharmacotherapy and the late complications of persistent uncontrolled HTN is the basic reason that these patients are a long-life follow-up population with important medical needs and increasing morbidity and mortality.
Библиографические ссылки
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2. Strafford MA, Griffiths SP, Gersony WM (1982) Coarctation of the aorta: A study in delayed detection. Pediatrics 69: 159-163. Link: https://goo.gl/pxFXRL
3. Rudolf AM (2009) Congenital Diseases of the Heart-Clinical & Physiological Considerations. Wiley-Blackwell 3ed Edition. Link: https://goo.gl/3lK1nG
4. Connolly HM, Huston J, Brown RD Jr, Warnes CA, Ammash NM, et al. (2003) Intracranial aneurysms in patients with coarctation of theaorta: a prospective magnetic resonance angiographic study of 100 patients. Mayo Clin Proc 78: 1491-1499.Link: https://goo.gl/DQHDvZ
5. Nguyen L, Cook S (2015) Coarctation of the Aorta. Strategies of improving outcome. Cardiology Clinics 33: 521–530. Link: https://goo.gl/95bsIy
6. Kaushal S, Backer CL, Patel JN, Patel SK, Walker BL, et al. (2009) Coarctation of the aorta: midterm outcomes of resection with extended end-to-end Anastomosis. Ann Thorac Surg 88: 1932–1938. Link: https://goo.gl/AZ5hME
7. Hamdan MA, Maheshwari S, Fahey JT, Hellenbrand WE (2001) Endovascular stents for coarctation of the aorta: Initial results and intermediate-term follow-up. J Am Coll Cardiol 38: 1518–1523. Link: https://goo.gl/PQJQFG
8. Kenny D, Polson JW, Martin RP, Paton JF, Wolf AR (2011) Hypertension and coarctation of the aorta: an inevitable consequence of developmental pathophysiology Hypertension. Research 34: 543–547. Link:
9. https://goo.gl/by757D
10. O’Sullivan JJ, Derrick G, Darnell R (2002) Prevalence of hypertension in children after early repair of coarctation of the aorta: a cohort study using casual and 24h blood pressure measurement. Heart 88: 163–166. . Link: https://goo.gl/ZWH5u2
11. Hager A, Kanz S, Kaemmerer H, Schreiber C, Hess J (2007) Coarctation long-term assessment (COALA): significance of arterial hypertension in a cohort of 404 patients up to 27 years after surgical repair of isolated coarctation of the aorta, even in the absence of restenosis and prosthetic material. J Thorac Cardiovasc Surg 134: 738–745. Link: https://goo.gl/hCfMOY
12. McBride KL, Pignatelli R, Lewin M, Ho T, Fernbach S, et al. (2005) Inheritance Analysis of Congenital Left Ventricular Outflow Tract Obstruction Malformations: Segregation, Multiplex Relative Risk, and Heritability. American Journal of Medical Genetics 134: 180–186. Link: https://goo.gl/e18wcO
13. McBride KL, Riley MF, Zender GA, Fitzgerald-Butt SM, Towbin JA. Et al. (2008) NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling. Journal Human Molecular Genetics 2886-2893. Link: https://goo.gl/6q9zw6
14. Oliver JM, Alonso-Gonzalez R, Gonzalez AE, Gallego P, Sanchez-Recalde A, et al. (2009) Risk of Aortic Root or Ascending Aorta Complications in Patients With Bicuspid Aortic Valve With and Without Coarctation of the Aorta. Am J Cardiol 104: 1001–1006. Link: https://goo.gl/F9s5ue
15. Pham PP, Moller JH, Hills C, Larson V, Pyles L (2009) Cardiac Catheterization and Operative Outcomes from a Multicenter Consortium for Children with Williams Syndrome. Pediatric Cardiology 30: 9–14. Link: https://goo.gl/O19s5R
16. Curtis SL, Bradley M, Wilde P, Aw J, Chakrabarti S, et al. (2012) Results of Screening for Intracranial Aneurysms in Patients with Coarctation of the Aorta. Am J Neuroradiol 33: 1182-1186. Link: https://goo.gl/ykNUHW
17. Allen HD, Gutgesell HP, Clark EB, Driscoll DJ (2001) “Moss and Adams”, Heart Disease in Infants, Children and Adolescents, including the Fetus and Young Adult. 6th Ed. Lippincott Williams & Wilkins. Link:
18. Anthony N (2007) Echocardiography in Hurst’s. The Heart 12th edition, McGraw Hill Medical, 443. Link:
19. Shepherd B, Abbas A, McParland P, Fitzsimmons S, Shambrook J, et al. (2015) MRI in adult patients with aortic coarctation: diagnosis and follow-up. Clin Radiol 70: 433–445. Link: https://goo.gl/pljMgE
20. Rosenthal E, Bell A (2010) Optimal imaging after coarctation stenting. Heart 96: 1169-1171. Link: https://goo.gl/sBhCno
21. Hager A, Kaemmerer H, Hess J (2005) Comparison of Helical CT Scanning and MRI in the Follow-up of Adults with Coarctation of the Aorta. Chest 127: 2296. Link: https://goo.gl/vK3rPg
22. Torok RD, Campbell MJ, Fleming GA, Hill KD (2015) Coarctation of the aorta: Management from infancy to Adulthood. World J Cardiol 7: 765-775. Link: https://goo.gl/ez57jE
23. Warnes CA, Williams RG, Bashore TM, Child JS, Connolly HM, et al. (2008) Guidelines for the Management of Adults with Congenital Heart Disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 118: 714-833. Link: https://goo.gl/Y4Y0EP
24. Cowley CG, Orsmond GS, Feola P, McQuillan L, Shaddy RE (2005) Long-term, randomized comparison of balloon angioplasty and surgery for native coarctation of the aorta in childhood. Circulation 111: 3453-3456. Link: https://goo.gl/lwVKts
25. Feltes TF, Bacha E, Beekman RH 3rd, Cheatham JP, Feinstein JA, et al. (2011) Indications for cardiac catheterization and intervention in pediatric cardiac disease: a scientific statement from the American Heart Association. Circulation 123: 2607-2652. Link: https://goo.gl/t1B7yz
26. Suradi H, Hijazi ZM (2015) Current management of coarctation of the aorta. Global Cardiology Science and Practice: 44: 2-11. Link: https://goo.gl/5QlR6S
27. Cohen M, Fuster V, Steele PM , Driscoll D, McGoon DC (1989) Coarctation of the Aorta Long-term Follow-up and Prediction of Outcome After Surgical Correction. Circulation 80: 840-845. Link: https://goo.gl/bbv2F8
28. Khavandi A, Bentham J, Marlais M, Martin RP, Morgan GJ, et al. (2013) Transcatheter and endovascular stent graft management of coarctation-related pseudoaneurysms. Heart 99: 1275-1281. Link: https://goo.gl/Ou2oPm
29. Patnana SR, Seib PM (2015) Coarctation of the Aorta. Link: medscape com/ article / 895502
30. Thoele DG, Muster AJ, Paul MH (1987) Recognition of coarctation of the aorta. A continuing challenge for the primary care physician Am J Dis Child 141: 1201-4. Link: https://goo.gl/kRadKr
31. Petropoulos A (2014) Hypertension in the Young An overgrowing concern in Pediatrics 2end BITS, Annual World Conference in Pediatrics, Abstract Book; Tayhan, China 24-26/10/2014 Link:
32. Bocelli A, Favilli S, Pollini I, Bini RM, Ballo P, et al. (2013) Prevalence and long-term predictors of left ventricular hypertrophy, late hypertension and hypertensive response to exercise after successful aortic coarctation repair . Pediatr Cardiol 34: 620–629. Link: https://goo.gl/EMbnoo
33. Mascherbauer J (2014) Mechanisms underlying arterial hypertension in contemporary patients with repaired aortic coarctation: do we know enough? Heart 0: 1–2. Link: https://goo.gl/xVG7mJ
34. Parker FB Jr, Farrell B, Streeten DH, Blackman MS, Sondheimer HM, et al. (1980) Hypertensive mechanisms in coarctation of the aorta—further-studies of the renin-angiotensin system. J Thorac Cardiovasc Surg 80: 568–573. Link: https://goo.gl/QpTUsp
35. Sangaleti CT, Crescenzi A, Michelini LC (2004) Endogenous angiotensin and pressure modulate brain angiotensinogen and at (1a) mRNA expression. Hypertension 43: 317–323. Link: https://goo.gl/1waobv
36. de Divitiis M, Pilla C, Kattenhorn M, Zadinello M, Donald A, et al. (2001) Vascular Dysfunction After Repair of Coarctation of the Aorta. Impact of Early Surgery. Circulation I-168. Link: https://goo.gl/aE5sjC
37. Baumgartner H, Bonhoeffer P, De Groot NM, de Haan F, Deanfield JE, et al. (2010) ESC Guidelines for the management of grown-up congenital heart disease (new version 2010). Eu Heart J 31: 2915–2957. Link: https://goo.gl/7E7ThC
38. Frobel AK, Hulpke-Wette M, Schmidt KG, Laer S (2009) Beta-blockers for congestive heart failure in children Cochrane Database. Syst Rev CD007037.
39. Chu PY, Campbell MJ, Miller SG, Hill KD (2014) Anti-hypertensive drugs in children and adolescents. World J Cardiol 6: 234-244. Link: https://goo.gl/zJb2ge
40. Flynn JT (2011) Management of hypertension in the young role of antihypertensive medications. J Cardiovasc Pharmacol 58: 111-120. Link: https://goo.gl/P8dSBg
41. Webb NJ, Lam C, Loeys T, Shahinfar S, Strehlau J, et al. (2010) Randomized, double-blind controlled study of losartan in children with proteinuria. Clin J Am Soc Nephrol 5: 417-424. Link: https://goo.gl/HWdTSl
42. Giordano U, Cifra B, Giannico S, Turchetta A, Calzolari A (2009) Mid-term results, and therapeutic management, for patients suffering hypertension after surgical repair of aortic coarctation. Cardiology in the Young 19: 451-455. Link: https://goo.gl/A4ie0f
2. Strafford MA, Griffiths SP, Gersony WM (1982) Coarctation of the aorta: A study in delayed detection. Pediatrics 69: 159-163. Link: https://goo.gl/pxFXRL
3. Rudolf AM (2009) Congenital Diseases of the Heart-Clinical & Physiological Considerations. Wiley-Blackwell 3ed Edition. Link: https://goo.gl/3lK1nG
4. Connolly HM, Huston J, Brown RD Jr, Warnes CA, Ammash NM, et al. (2003) Intracranial aneurysms in patients with coarctation of theaorta: a prospective magnetic resonance angiographic study of 100 patients. Mayo Clin Proc 78: 1491-1499.Link: https://goo.gl/DQHDvZ
5. Nguyen L, Cook S (2015) Coarctation of the Aorta. Strategies of improving outcome. Cardiology Clinics 33: 521–530. Link: https://goo.gl/95bsIy
6. Kaushal S, Backer CL, Patel JN, Patel SK, Walker BL, et al. (2009) Coarctation of the aorta: midterm outcomes of resection with extended end-to-end Anastomosis. Ann Thorac Surg 88: 1932–1938. Link: https://goo.gl/AZ5hME
7. Hamdan MA, Maheshwari S, Fahey JT, Hellenbrand WE (2001) Endovascular stents for coarctation of the aorta: Initial results and intermediate-term follow-up. J Am Coll Cardiol 38: 1518–1523. Link: https://goo.gl/PQJQFG
8. Kenny D, Polson JW, Martin RP, Paton JF, Wolf AR (2011) Hypertension and coarctation of the aorta: an inevitable consequence of developmental pathophysiology Hypertension. Research 34: 543–547. Link:
9. https://goo.gl/by757D
10. O’Sullivan JJ, Derrick G, Darnell R (2002) Prevalence of hypertension in children after early repair of coarctation of the aorta: a cohort study using casual and 24h blood pressure measurement. Heart 88: 163–166. . Link: https://goo.gl/ZWH5u2
11. Hager A, Kanz S, Kaemmerer H, Schreiber C, Hess J (2007) Coarctation long-term assessment (COALA): significance of arterial hypertension in a cohort of 404 patients up to 27 years after surgical repair of isolated coarctation of the aorta, even in the absence of restenosis and prosthetic material. J Thorac Cardiovasc Surg 134: 738–745. Link: https://goo.gl/hCfMOY
12. McBride KL, Pignatelli R, Lewin M, Ho T, Fernbach S, et al. (2005) Inheritance Analysis of Congenital Left Ventricular Outflow Tract Obstruction Malformations: Segregation, Multiplex Relative Risk, and Heritability. American Journal of Medical Genetics 134: 180–186. Link: https://goo.gl/e18wcO
13. McBride KL, Riley MF, Zender GA, Fitzgerald-Butt SM, Towbin JA. Et al. (2008) NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling. Journal Human Molecular Genetics 2886-2893. Link: https://goo.gl/6q9zw6
14. Oliver JM, Alonso-Gonzalez R, Gonzalez AE, Gallego P, Sanchez-Recalde A, et al. (2009) Risk of Aortic Root or Ascending Aorta Complications in Patients With Bicuspid Aortic Valve With and Without Coarctation of the Aorta. Am J Cardiol 104: 1001–1006. Link: https://goo.gl/F9s5ue
15. Pham PP, Moller JH, Hills C, Larson V, Pyles L (2009) Cardiac Catheterization and Operative Outcomes from a Multicenter Consortium for Children with Williams Syndrome. Pediatric Cardiology 30: 9–14. Link: https://goo.gl/O19s5R
16. Curtis SL, Bradley M, Wilde P, Aw J, Chakrabarti S, et al. (2012) Results of Screening for Intracranial Aneurysms in Patients with Coarctation of the Aorta. Am J Neuroradiol 33: 1182-1186. Link: https://goo.gl/ykNUHW
17. Allen HD, Gutgesell HP, Clark EB, Driscoll DJ (2001) “Moss and Adams”, Heart Disease in Infants, Children and Adolescents, including the Fetus and Young Adult. 6th Ed. Lippincott Williams & Wilkins. Link:
18. Anthony N (2007) Echocardiography in Hurst’s. The Heart 12th edition, McGraw Hill Medical, 443. Link:
19. Shepherd B, Abbas A, McParland P, Fitzsimmons S, Shambrook J, et al. (2015) MRI in adult patients with aortic coarctation: diagnosis and follow-up. Clin Radiol 70: 433–445. Link: https://goo.gl/pljMgE
20. Rosenthal E, Bell A (2010) Optimal imaging after coarctation stenting. Heart 96: 1169-1171. Link: https://goo.gl/sBhCno
21. Hager A, Kaemmerer H, Hess J (2005) Comparison of Helical CT Scanning and MRI in the Follow-up of Adults with Coarctation of the Aorta. Chest 127: 2296. Link: https://goo.gl/vK3rPg
22. Torok RD, Campbell MJ, Fleming GA, Hill KD (2015) Coarctation of the aorta: Management from infancy to Adulthood. World J Cardiol 7: 765-775. Link: https://goo.gl/ez57jE
23. Warnes CA, Williams RG, Bashore TM, Child JS, Connolly HM, et al. (2008) Guidelines for the Management of Adults with Congenital Heart Disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 118: 714-833. Link: https://goo.gl/Y4Y0EP
24. Cowley CG, Orsmond GS, Feola P, McQuillan L, Shaddy RE (2005) Long-term, randomized comparison of balloon angioplasty and surgery for native coarctation of the aorta in childhood. Circulation 111: 3453-3456. Link: https://goo.gl/lwVKts
25. Feltes TF, Bacha E, Beekman RH 3rd, Cheatham JP, Feinstein JA, et al. (2011) Indications for cardiac catheterization and intervention in pediatric cardiac disease: a scientific statement from the American Heart Association. Circulation 123: 2607-2652. Link: https://goo.gl/t1B7yz
26. Suradi H, Hijazi ZM (2015) Current management of coarctation of the aorta. Global Cardiology Science and Practice: 44: 2-11. Link: https://goo.gl/5QlR6S
27. Cohen M, Fuster V, Steele PM , Driscoll D, McGoon DC (1989) Coarctation of the Aorta Long-term Follow-up and Prediction of Outcome After Surgical Correction. Circulation 80: 840-845. Link: https://goo.gl/bbv2F8
28. Khavandi A, Bentham J, Marlais M, Martin RP, Morgan GJ, et al. (2013) Transcatheter and endovascular stent graft management of coarctation-related pseudoaneurysms. Heart 99: 1275-1281. Link: https://goo.gl/Ou2oPm
29. Patnana SR, Seib PM (2015) Coarctation of the Aorta. Link: medscape com/ article / 895502
30. Thoele DG, Muster AJ, Paul MH (1987) Recognition of coarctation of the aorta. A continuing challenge for the primary care physician Am J Dis Child 141: 1201-4. Link: https://goo.gl/kRadKr
31. Petropoulos A (2014) Hypertension in the Young An overgrowing concern in Pediatrics 2end BITS, Annual World Conference in Pediatrics, Abstract Book; Tayhan, China 24-26/10/2014 Link:
32. Bocelli A, Favilli S, Pollini I, Bini RM, Ballo P, et al. (2013) Prevalence and long-term predictors of left ventricular hypertrophy, late hypertension and hypertensive response to exercise after successful aortic coarctation repair . Pediatr Cardiol 34: 620–629. Link: https://goo.gl/EMbnoo
33. Mascherbauer J (2014) Mechanisms underlying arterial hypertension in contemporary patients with repaired aortic coarctation: do we know enough? Heart 0: 1–2. Link: https://goo.gl/xVG7mJ
34. Parker FB Jr, Farrell B, Streeten DH, Blackman MS, Sondheimer HM, et al. (1980) Hypertensive mechanisms in coarctation of the aorta—further-studies of the renin-angiotensin system. J Thorac Cardiovasc Surg 80: 568–573. Link: https://goo.gl/QpTUsp
35. Sangaleti CT, Crescenzi A, Michelini LC (2004) Endogenous angiotensin and pressure modulate brain angiotensinogen and at (1a) mRNA expression. Hypertension 43: 317–323. Link: https://goo.gl/1waobv
36. de Divitiis M, Pilla C, Kattenhorn M, Zadinello M, Donald A, et al. (2001) Vascular Dysfunction After Repair of Coarctation of the Aorta. Impact of Early Surgery. Circulation I-168. Link: https://goo.gl/aE5sjC
37. Baumgartner H, Bonhoeffer P, De Groot NM, de Haan F, Deanfield JE, et al. (2010) ESC Guidelines for the management of grown-up congenital heart disease (new version 2010). Eu Heart J 31: 2915–2957. Link: https://goo.gl/7E7ThC
38. Frobel AK, Hulpke-Wette M, Schmidt KG, Laer S (2009) Beta-blockers for congestive heart failure in children Cochrane Database. Syst Rev CD007037.
39. Chu PY, Campbell MJ, Miller SG, Hill KD (2014) Anti-hypertensive drugs in children and adolescents. World J Cardiol 6: 234-244. Link: https://goo.gl/zJb2ge
40. Flynn JT (2011) Management of hypertension in the young role of antihypertensive medications. J Cardiovasc Pharmacol 58: 111-120. Link: https://goo.gl/P8dSBg
41. Webb NJ, Lam C, Loeys T, Shahinfar S, Strehlau J, et al. (2010) Randomized, double-blind controlled study of losartan in children with proteinuria. Clin J Am Soc Nephrol 5: 417-424. Link: https://goo.gl/HWdTSl
42. Giordano U, Cifra B, Giannico S, Turchetta A, Calzolari A (2009) Mid-term results, and therapeutic management, for patients suffering hypertension after surgical repair of aortic coarctation. Cardiology in the Young 19: 451-455. Link: https://goo.gl/A4ie0f
Ключевые слова
secondary hypertension
coarctation of aorta коарктация
аорта
гипертония koarktasiya
aorta
hipertoniya
coarctation of aorta коарктация
аорта
гипертония koarktasiya
aorta
hipertoniya
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