e-ISSN: 2617-7668
print ISSN: 2522-9176
Congenital Heart Disease and Maternal Diabetes Mellitus
Review Article
Congenital Heart Disease and Maternal Diabetes Mellitus
Published: June 6, 2018
Abstract
Diabetes mellitus is a relatively common illness that can complicate pregnancy and result in an increased incidence of congenital malformations. Offspring of diabetic mothers suffering from type IDDM have a fivefold incidence of congenital malformations compared to pregnancies in the general healthy population. Specifically, the pattern of congenital heart disease (CHD) encountered among this group, with an emphasis on abnormalities of laterality, looping and conotruncal septation, suggesting that the maternal metabolic state affects cardiogenesis at a very early stage of the developmental period, prior to 7 weeks of gestation. Although many have been written on the effect of diabetes in pregnant women, less is known for the effects of type II DM and gestational diabetes mellitus (GDM) and its role in provoking CHD.
Aim of this paper is to review the literature regarding the types of CHD seen in offspring of mothers suffering from different types of diabetes mellitus, maternal types 1 and 2 and gestational and to comment on the incidences and any differences found in the types of detected CHD.
References
1. Molsted-Pedersen L, Tygstrup I, Pedersen J. (1964) Congenital malformations in newborn infants of diabetic women. Lancet 1:1124-6.
2. Casson IF, Clarke CA, Howard CV, McKendrick O, Pennycook S, Pharoah PO, Platt MJ, Stanisstreet M, Van-Velszen D, Walkinshaw S. (1997) Outcomes of pregnancy in insulin dependent diabetic women: results of a five year population cohort study. BMJ 315: 275-8.
3. Lowy C, Beard RW, Goldschmidt J. (1986) The UK diabetic pregnancy survey. Acta Endocrinol Suppl (Copenh) 277:86-9.
4. Becerra JE, Khoury MJ, Cordero JF, Erickson JD. (1990) Diabetes mellitus during pregnancy and the risks for specific birth defects: a population-based case-control study. Pediatrics 85:1-9.
5. Shaw GM, Quach T, Nelson V, Carmichael SL, Schaffer DM, et al. (2003) Neural tube defects associated with maternal periconceptional dietary intake of simple sugars and glycemic index. Am J Clin Nutr 78: 972-978.
6. Metzger BE, Lowe LP, Dyer AR, Trimble ER, et al. (2008) Hyperglycemia and adverse pregnancy outcomes. HAPO Study Cooperative Research Group N Engl J Med 358:1991-2002.
7. Global status report on non-communicable diseases (2014). Geneva, World Health Organization, 2012.
8. Assiamira Ferrara. (2007) Increasing prevalence of GDM. Diabetes Care, Vol 30, Supp. 2.
9. Balsells M, García-Patterson A, Gich I, Corcoy R. (2012) Major congenital malformations in women with gestational diabetes mellitus: a systematic review and meta-analysis. Diabetes Metab Res Rev 28: 252-257.
10. Charles F Potter, Ted Rosenkrantz, (May 2013) Infant of diabetic mother; Medscape Education, Medline.
11. Lindsey D. Allan, Ggurleen K. Sharland, Anna Milburn et al. (May 1994) Prospective Diagnosis of 1,006 Consecutive Cases of Congenital Heart Disease in the Fetus. JACC Vol 23 no 6, 452-8.
12. Ullmo S, Vial Y, Di Bernardo S, Roth-Kleiner M, Mivelaz Y, SekarskiN, et al. (2007) Pathologic ventricular hypertrophy in the offspring of diabetic mothers: a retrospective study. Eur Heart J. : 28(11):1319-25.
13. Pildes RS. (1973) Infants of diabetic mothers. N Engl J Med. 289 (17):902-4.
14. Sardesai MG, Gray AA, McGrath MM, Ford SE. (2001) Fatal hypertrophic cardiomyopathy in the fetus of a woman with diabetes. Obstet Gynecol 98:925–927.
15. Lisowski LA, Verheijen PM, Copel JA, Kleinman CS, Wassink S, Visser GH, et al. (2010) Congenital heart disease in pregnancies complicated by maternal diabetes mellitus. An international clinical collaboration, literature review, and meta-analysis. Herz 35(1):19-26.
16. Wren C, Birrell G, Hawthorne G. (2003) Cardiovascular malformations in infants of diabetic mothers. Heart 89(10):1217-20.
17. Vela-Huerta M, Aguilera-Lopez A, Alarcon-Santos S, Amador N, Aldana-Valenzuela C, Heredia A. (2007) Cardiopulmonary adaptationin large for gestational age infants of diabetic and non-diabetic mothers. Acta Paediatr 96(9):1303-7.
18. R.M. Abu-Sulaiman,B. Subaih. (2004) Congenital Heart Disease in Infants of Diabetic Mothers: Echocardiographic Study; Pediatr Cardiol 25:137–140.
2. Casson IF, Clarke CA, Howard CV, McKendrick O, Pennycook S, Pharoah PO, Platt MJ, Stanisstreet M, Van-Velszen D, Walkinshaw S. (1997) Outcomes of pregnancy in insulin dependent diabetic women: results of a five year population cohort study. BMJ 315: 275-8.
3. Lowy C, Beard RW, Goldschmidt J. (1986) The UK diabetic pregnancy survey. Acta Endocrinol Suppl (Copenh) 277:86-9.
4. Becerra JE, Khoury MJ, Cordero JF, Erickson JD. (1990) Diabetes mellitus during pregnancy and the risks for specific birth defects: a population-based case-control study. Pediatrics 85:1-9.
5. Shaw GM, Quach T, Nelson V, Carmichael SL, Schaffer DM, et al. (2003) Neural tube defects associated with maternal periconceptional dietary intake of simple sugars and glycemic index. Am J Clin Nutr 78: 972-978.
6. Metzger BE, Lowe LP, Dyer AR, Trimble ER, et al. (2008) Hyperglycemia and adverse pregnancy outcomes. HAPO Study Cooperative Research Group N Engl J Med 358:1991-2002.
7. Global status report on non-communicable diseases (2014). Geneva, World Health Organization, 2012.
8. Assiamira Ferrara. (2007) Increasing prevalence of GDM. Diabetes Care, Vol 30, Supp. 2.
9. Balsells M, García-Patterson A, Gich I, Corcoy R. (2012) Major congenital malformations in women with gestational diabetes mellitus: a systematic review and meta-analysis. Diabetes Metab Res Rev 28: 252-257.
10. Charles F Potter, Ted Rosenkrantz, (May 2013) Infant of diabetic mother; Medscape Education, Medline.
11. Lindsey D. Allan, Ggurleen K. Sharland, Anna Milburn et al. (May 1994) Prospective Diagnosis of 1,006 Consecutive Cases of Congenital Heart Disease in the Fetus. JACC Vol 23 no 6, 452-8.
12. Ullmo S, Vial Y, Di Bernardo S, Roth-Kleiner M, Mivelaz Y, SekarskiN, et al. (2007) Pathologic ventricular hypertrophy in the offspring of diabetic mothers: a retrospective study. Eur Heart J. : 28(11):1319-25.
13. Pildes RS. (1973) Infants of diabetic mothers. N Engl J Med. 289 (17):902-4.
14. Sardesai MG, Gray AA, McGrath MM, Ford SE. (2001) Fatal hypertrophic cardiomyopathy in the fetus of a woman with diabetes. Obstet Gynecol 98:925–927.
15. Lisowski LA, Verheijen PM, Copel JA, Kleinman CS, Wassink S, Visser GH, et al. (2010) Congenital heart disease in pregnancies complicated by maternal diabetes mellitus. An international clinical collaboration, literature review, and meta-analysis. Herz 35(1):19-26.
16. Wren C, Birrell G, Hawthorne G. (2003) Cardiovascular malformations in infants of diabetic mothers. Heart 89(10):1217-20.
17. Vela-Huerta M, Aguilera-Lopez A, Alarcon-Santos S, Amador N, Aldana-Valenzuela C, Heredia A. (2007) Cardiopulmonary adaptationin large for gestational age infants of diabetic and non-diabetic mothers. Acta Paediatr 96(9):1303-7.
18. R.M. Abu-Sulaiman,B. Subaih. (2004) Congenital Heart Disease in Infants of Diabetic Mothers: Echocardiographic Study; Pediatr Cardiol 25:137–140.
Keywords
gestational diabetes
fetal cardiac screening
congenital heart disease гестационный диабет
врожденные пороки сердца
фетальный скрининг diabet
fetal skrininq
anadangəlmə ürək qüsuru
fetal cardiac screening
congenital heart disease гестационный диабет
врожденные пороки сердца
фетальный скрининг diabet
fetal skrininq
anadangəlmə ürək qüsuru
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