Natural history and predictors of poor outcomes in acute liver injury patients in a setting without liver transplant facility

Abstract

Hepatitis is one of the leading causes of mortality globally and Pakistan, too, has a very high burden of liver disease and associated morbidity and mortality. Significant burden combined with lack of adequate transplant facilities make it crucial to understand predictors and natural history of more severe stages of liver damage or inflammation, such as acute liver injury, as is the aim of this study. Even though it is known that Acute Liver Injury (ALI) is defined as INR ≥ 2.0, ALT ≥ 10X ULN, and Total Bilirubin ≥ 3 mg/dl, there is a dearth of literature on factors and prognosis associated with ALI.