HDV ilə əlaqəli xroniki hepatit olan müalicə olunmamış və Myrcludex-B müalicə olunan üç HDV-RNA nizamlı ticari olaraq mövcud testlərin real həyat şəraitində müqayisə edilməsi

Annotasiya

As new anti-hepatitis delta (HDV) therapies are being developed, highly sensitive and reliable quantitative tests are needed. Aim of the study was to compare three commercially available HDV-RNA kits. Methods. 92 serum samples from 4 categories of patients were tested for HDV-RNA by 3 assays: RoboGene (HDV-RNA quantification 2.0, Aj-Roboscreen, Germany, LLQ 6 IU/mL), EurobioPlex (HDV qRT-PCR, Eurobio, France, 100 IU/mL) and Dia.Pro (HDV-RNA Quantitation, Dia.Pro Diagnostic Bioprobes, Italy, 50 IU/mL). Total RNA was extracted by EZ1 DSP Virus Kit (Qiagen, Hilden, Germany).