ABCB1( P-glycoprotein) and TOP2A as predictive markers for anthracycline and taxane-containing chemotherapy regimens in neoadjuvant treatment of breast cancer

Abstract

 Topoisomerase II alpha (TOP2A) and    protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The predictive significance of  TOP2A and ABCB1 together  seems different among different subtypes of breast cancer. Our  study evaluated the predictive impact of TOP2A and  ABCB1  protein on  breast cancer patients to whom prescribed neoadjuvant chemotherapy.